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1.
Chinese Journal of Virology ; (6): 78-83, 2012.
Artigo em Chinês | WPRIM | ID: wpr-354767

RESUMO

ISG15 is a 15kD ubiquitin-like protein (UBL) induced by interferon (IFN). ISG15 can be covalently attached to proteins, which is called ISGylation process. ISGylation system contains ISG15, UBE1L, UBCH8 and HERC5 proteins, which are all essential for ISGylation. ISG15 and ISGylation system have been found to have anti-viral effects. A better understanding of how ISG15 mediates the anti-viral activity will provide insights for new anti-viral drugs development and new therapeutic strategies. The mechanisms underlying the ISG15 mediated anti-viral response have been explored extensively in recent years. This minireview summarized the research advances of how ISG15 mediated the anti-viral effects against different kinds of viruses.


Assuntos
Animais , Humanos , Citocinas , Fisiologia , Infecções por HIV , Alergia e Imunologia , Influenza Humana , Alergia e Imunologia , Ubiquitinas , Fisiologia , Viroses , Alergia e Imunologia
2.
Chinese Journal of Virology ; (6): 462-470, 2012.
Artigo em Chinês | WPRIM | ID: wpr-340022

RESUMO

Tumor suppressor p53, known as 'the guardian of the genome', has the ability to prevent the emergence of transformed cells by the induction of cell cycle arrest and apoptosis. Otherwise, there were researches about the function of p53, such as NDA repair, regulating metabolism and maternal reproduction in recent years. Furthermore, there was a new function for p53 in antiviral apoptosis mentioned in the research, Integration of interferon-alpha/beta signaling to p53 responses in tumour suppression and antiviral defense. In order to define the antiviral function of p53, many target genes has been defined, such as IRF9, IRF5, ISG15 and TLR3. All of these implied there must be a complex mechanism for role of p53 in antiviral innate immunity, adaptive immunity and inflammation.


Assuntos
Animais , Humanos , Fenômenos Fisiológicos Celulares , Imunidade , Inflamação , Alergia e Imunologia , Metabolismo , Virologia , Proteína Supressora de Tumor p53 , Genética , Metabolismo , Vírus , Alergia e Imunologia
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